Endometriosis and Pelvic Pain

Endometriosis and Pelvic Pains or Cramps
Endometriosis is a result of COX-2 over-expression for excessive prostaglandin E-2 production in the local cells of pelvic tissues, including the ovaries, fallopian tubes, outer surface of the uterus, rectum, cervix, bladder, vagina or anus. A recent study (published in Sept, 2005) shows the prostaglandin E-2 concentration in the peritoneal fluid and serum of the patients will have about 2-5 times and 2-30 times, respectively, more than the normal women's. Therefore, it is an inflammation phenomenon, not a migration of the uterine lining tissue (endometrial cells) ! Excessive estrogen with a deficiency of progesterone and androstenedione/testosterone/DHT will promote prostaglandin E-2 production and suppress the housekeeping prostaglandin E-1 release, leading to the inflammation of the local nerves. In this regard, the androgen hormones androstenedione/testosterone/DHT plays the key role in the regulation of the prostaglandins balance since excessive progesterone in the Luteal Phase causes PMS too, while pregnant women with a high level of estrogen and progesterone and a suitable of androgen hormones will produce a lot of prostaglandin E-1 and E-2 in their uterus for the uterine expansion without pains during fetal development! When the progesterone level drops and the cortisol level jumps up, the prostaglandin E-2 production overshot the prostaglandin E-1 level in the uterus and cervix to induce labor contraction and pains. Therefore, the solution for Endometriosis includes reduction of estrogen synthesis, enhancement of the androgen hormones, and reduction of the stress hormones epinephrine and cortisol with enhancement of cortisone level.

Prostaglandin E2 can help unwanted or migrating tissues or cells to adhere or implant in the adjacent tissues since prostaglandin E2 help sperm cells to penetrate the egg "shell" for fertilization and then help the fertilized egg to penetrate into the uterine lining for implantation. Any floating or migrating cells can attach or adhere to the main body cells with help of prostaglandin E2. Thus, prostaglandin E2 helps organ transplant. The same situation is also applied to re-attachment of the debris or cells of the uterine lining into the ovarian tubes or vagina. This is called adhesion. The adhered cells can grow out of bound and spread into the adjacent organs. This can cause pelvic pains. This is the conventional definition of Endometriosis.

On the other hand, prostaglandin E2 can inflame the tissues, blood vessels and nerves for pains and cramps, form collagen tissues leading to nervous numbness and blocking blood circulation, or alternate cellular DNA to turn good cells into tumor or cancer outgrowth and pains.

Ref: http://ajp.amjpathol.org/cgi/content/full/167/4/1061

Most women who start to experience Endometriosis just have an excessive inflammatory hormones release which can be solved by our ViaPla-hGH-E or ViaPal-hGH-M with a high dose of Fish Oil.

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